Assistant Professor, Basic Pharmaceutical Sciences
Dr. Zhang’ s research interests are in the area of utilizing pharmacokinetic/pharmacodynamic (PK/PD) modeling, and physiologically based pharmacokinetic (PBPK) modeling and simulation tools (Phoenix WinNonlin, Simcyp, Gastroplus, etc) to analyze analysis of preclinical and clinical PK/PD data, predict PK profile and exposure, and explore drug-drug interaction potential. One ongoing project is pharmacokinetic modeling and dose optimization of antiepileptic drugs (AEDs) in adult and pediatric patient population. The model will enhance our understanding of the absorption and disposition of various formulations of Divalproex sodium (DVP), especially the extended-release formulations. It will be valuable to design individualized DVP and other AED dosing regimens.
Another research area actively pursued is to identify compounds that inhibit proliferation and self-renewal of cancer stem cells. It has been suggested that many types of cancer are initiated from and maintained by a small population of cancer stem cells (CSCs). The CSC population produces the tumor bulk through continuous self-renewal and differentiation. The current research is to explore the molecular mechanism of anti-CSC compounds (e.g., sulforaphane) and enhance the delivery and potency of those compounds against CSCs.
1.Binfeng Xia, Avantika Barve, Tycho Heimbach, Tao Zhang, Helen Gu, Lai Wang, Heidi Einolf, Natalya Alexander, Imad Hanna, June Ke, James B Mangold, Handan He, Gangadhar Sunkara. Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir. Eur J Pharm Sci. 2014 Jul 4. pii: S0928-0987(14)00281-4. doi: 10.1016/j.ejps.2014.06.021[Epub ahead of print].
2.Yanyan Li, Tao Zhang. Targeting of cancer stem cells by curcumin and clinical applications. Cancer Letters, 2014 Jan 23 [Epub ahead of print].
3.Tao Zhang, Yanyan Li, Peng Zou, Jing-yu Yu, Donna McEachern, Shaomeng Wang, Duxin Sun. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of an Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in a Mouse Xenograft Model of Human Breast Cancer. Biopharm Drug Dispos 2013 Sep; 34(6): 348-59.
4.Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Steven J. Schwartz, Duxin Sun. Kinetics of Sulforaphane in Mice after Consumption of Sulforaphane-Enriched Broccoli Sprout Preparation. Molecular Nutrition & Food Research 2013 Dec; 57(12):2128-36.
5.Yanyan Li, Tao Zhang. Targeting Cancer Stem Cells by Sulforaphane, a Dietary Component from Broccoli and Broccoli Sprouts. Future Oncology 2013 Aug; 9(8):1097-103.
6.Tao Zhang, Yanyan Li, Zhenkun Zhu, Mancang Gu, Bryan Newman, Duxin Sun. MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells. Molecular Pharmaceutics, 2010; 7(5): 1576–1584.
7.Yanyan Li, Tao Zhang, Hasan Korkaya, Suling Liu, Hsiu-Fang Lee, Bryan Newman, Yanke Yu, Shawn G. Clouthier, Steven J. Schwartz, Max S. Wicha, and Duxin Sun. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res, 2010; 16(9): 2580-90.
8.Tao Zhang, Yanyan Li, Yanke Yu, Peng Zou, Yiqun Jiang, and Duxin Sun. Characterization of celastrol to inhibit Hsp90 and Cdc37 interaction. J Biol Chem, 2009; 284(51): 35381-9.
9.Yanyan Li*, Tao Zhang*, Yiqun Jiang, Hsiu-Fang Lee, Steven J. Schwartz and Duxin Sun. (-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Cochaperones in Pancreatic Cancer Cell Line Mia Paca-2. Molecular Pharmaceutics, 2009 Jul-Aug; 6(4):1152-9. *equal authorship
10.Yanyan Li*, Tao Zhang*, Steven J. Schwartz and Duxin Sun. New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential. Drug Resistance Updates, 2009; 12(1): 17-27. *equal authorship
11.Tao Zhang, Adel Hamza, Xianhua Cao, Bing Wang, Shuwen Yu, Chang-Guo Zhan and Duxin Sun. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Molecular Cancer Therapeutics, 2008 7:162-170
12.Tao Zhang, Cathie D. Xiang, David Gale, Samantha Carreiro, Ellen Y. Wu, and Eric Y. Zhang. Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition. Drug Metab Dispos, 2008; 36(7):1300-7.