Assistant Professor , Nutrition
Dr. Li’s research endeavors center around several critical aspects of phytochmicals with health benefits, particularly cancer chemopreventive properties, using interdisciplinary approaches. Her current research interests include:
1. Discovery of phytochemicals targeting cancer and cancer stem cells (CSCs) and efficacy evaluation in combination with cancer therapy.
2. Human observational and intervention studies to evaluate the effectiveness of nutrition education programs in local community.
3. Development of phytochemical-enriched dietary supplements and functional foods.
1. Yanyan Li, Tao Zhang. Targeting of cancer stem cells by curcumin and clinical applications. Cancer Letters, 2014; 346(2): 197-205.
2. Yanyan Li, Katlyn M. Soriano. African American females: a potential link between vitamin D insufficiency and type-2 diabetes. Journal of Nutritional Health & Food Engineering, 2014; 1(3): 00015.
3. Yanyan Li, Haiyan Su, John J. Specchio, John P. Schrade, Samuel Chung, and Mandy Unanski. Utilization of steam heat generated via microwave energy in seafood cooking. Journal of Nutritional Health & Food Engineering, 2014; 1(1): 00003.
4. Yanyan Li, Haiyan Su, John P. Schrade, and John J. Specchio. Transportation of perishable foods in insulated containers: a time-temperature study. Journal of Food Protection. 2014; 77(8): 1317-24.
5. Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Duxin Sun, and Steven J. Schwartz. Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation. Mol Nutr Food Res, 2013; 57(12): 2128-36.
6. Yanyan Li, Tao Zhang. Targeting cancer stem cells by sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncol, 2013; 9(8): 1097-103.
7. Tao Zhang, Yanyan Li, Peng Zou, Jing-yu Yu, Donna McEachern, David D’Argenio, Shaomeng Wang, and Duxin Sun. Physiologically based pharmacokinetic and pharmacodynamics modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharm Drug Dispos, 2013; 34(6): 348-59.
8. Yanyan Li, G. Elif Karagoz, Young Ho Seo, Tao Zhang, Yiqun Jiang, Yanke Yu, Steven J. Schwartz, Kate Carroll, Stefan Rudiger, and Duxin Sun. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50Cdc37 complex and direct interactions with amino acid residues of Hsp90. J Nutr Biochem, 2012; 23(12): 1617-26.
9. Yanyan Li, Tao Zhang, Steven J. Schwartz, and Duxin Sun. Sulforaphane potentiates the therapeutic efficacy of 17-AAG against pancreatic cancer by enhancing 17-AAG-induced abrogation of Hsp90 chaperone function. Nutr Cancer, 2011; 63(7): 1151-9.
10. Yanyan Li, Max S. Wicha, Steven J. Schwartz, and Duxin Sun. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem, 2011; 22(9): 799-806.
11. Yanyan Li, Steven J. Schwartz, and Duxin Sun. Book chapter: Potential application of natural dietary components to target cancer stem cells, in “Cancer Stem Cells – The Cutting Edge”, Stanley Shostak, Editor, InTech Publishing, August 2011. ISBN 978-953-307-580-8.
12. Yanyan Li, Tao Zhang, Hasan Korkaya, Suling Liu, Hsiu-Fang Lee, Bryan Newman, Yanke Yu, Shawn G. Clouthier, Steven J. Schwartz, Max S. Wicha, and Duxin Sun. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res, 2010; 16(9): 2580-90.
13. Tao Zhang, Yanyan Li, Zhenkun Zhu, Mancang Gu, Bryan Newman, and Duxin Sun. MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells. Mol Pharm, 2010; 7(5): 1576-84.
14. Yiqun Jiang, Denzil Bernard, Yanke Yu, Tao Zhang, Yanyan Li, Shaomeng Wang, Xueqi Fu, and Duxin Sun. Split renilla luciferase protein-fragment-assisted complementation (SRL-PFAC) to characterize Hsp90/p50Cdc37 complex and identify critical residues in protein-protein interactions. J Biol Chem, 2010; 285(27): 21023-36.
15. Yanke Yu, Adel Hamza, Tao Zhang, Mancang Gu, Peng Zou, Bryan Newman, Yanyan Li, A.A. Leslie Gunatilaka, Chang-Guo Zhan, and Duxin Sun. Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol, 2010; 79(4): 542-51.
16. Yanyan Li, Tao Zhang, Yiqun Jiang, Hsiu-Fang Lee, Steven J. Schwartz, and Duxin Sun. (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with co-chaperones in pancreatic cancer cell line Mia Paca-2. Mol Pharm, 2009; 6(4): 1152-9.
17. Yanyan Li, Tao Zhang, Steven J. Schwartz, and Duxin Sun. New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updates, 2009; 12(1): 17-27.
18. Tao Zhang, Yanyan Li, Yanke Yu, Peng Zou, Yiqun Jiang, and Duxin Sun. Characterization of celastrol to inhibit Hsp90 and p50Cdc37 interaction. J Biol Chem, 2009; 284(51): 35381-9.
Assistant Professor, School of Science and Humanities
Instructor, School of Science and Humanities
Instructor, Mathematics, School of Science and Humanities
Assistant Professor, Biology, School of Science and Humanities
Coordinator, Writing Center, School of Science and Humanities
Editor of Crosscut
Associate Professor of English, English Program
Assistant Professor and Laboratory Supervisor, School of Science and Humanities
Director of Healthcare Studies, School of Science and Humanities
Associate Professor, School of Science and Humanities
Associate Professor, Psychology
Professor, Chemistry, School of Science and Humanities
Assistant Professor, Studio Arts
Assistant Professor, Psychology, School of Science and Humanities
Instructor, English, School of Science and Humanities
Assistant Professor, Mathematics, School of Science and Humanities
Director of Institutional Research, Academic Administration, Provost's Office
Professor *Administrator with Faculty Rank, Mathematics/Statistics
Gail has been consulting with health professionals for over 20 years. Her expertise is in clinical trials, categorical data analysis and online instruction. She currently consults with medical professionals and faculty from the University of New England, University of Maine, University of North Carolina and Eastern Maine Medical Center on a regular basis. Gail has successfully collaborated with 12 different principal investigators on 15 grants over the last 20 years. As a public health professional she is particularly interested in research that concentrates on affordable ways to get a large amount of individuals to change their behavior in a positive way. Studying the relationship between providers and patients is an effective way to do this as patients with chronic disease visit their health care provider regularly and the provider can use these visits to educate their patients.
Sample of Refereed articles (published)
* Sleath, BL, Carpenter, DM, Slota C, Williams, DM, Tudor, G, Yeatts, K, , Davis, S and
Ayala GX (2012). Communication during pediatric asthma visits and self-reported asthma
medication adherence, Pediatrics, In print.
* Sleath B, Ayala GX, Williams D, Davis S, Yeatts K , Tudor G, Washington D, and
Gillete C (2011). Caregiver rating of provider participatory decision-making style and caregiver
and child satisfaction with pediatric asthma visits. Patient Education and Counseling. Vol. 85,
Issue 2, pp 286-289.
* Murphy, L, Helmick, CG, Schwartz, T, Renner, JB, Tudor G, Koch G, Dragomir A,
Kalsbeek WD, Luta G, Jordan JM (2010). One in four people may develop symptomatic hip
osteoarthritis in their lifetime. Osteoarthritis and Cartilage. Vol 18 (11), pp. 1372-1379.
* Sleath B, Ayala GX, Davis S, Williams D, Tudor G, Yeatts K, Washington D, Gillete
C (2010). Child- and caregiver-reported problems and concerns in using asthma medications. J
Asthma. 47(6): 633-8.
* Beard AJ, Sleath B, Blalock SJ, Roth M, Weinberger M, Tudor G, and Chewning B.
(2010). Predictors of rheumatoid arthritis Patient-physician communication about medication
costs during visits to rheumatologists. Arthritic Care and Research, Vol. 62. No. 5, pp 632-639.
* Sleath, BL, Krishnadas, R, Cho, M., Robin, AL, Mehta, R., Covert, D., Tudor, G.
(2009) Patient-reported barriers to glaucoma medication access, use, and adherence in southern
India Indian J Ophthalmol: 57:69-74
* Sleath B, Chewning B, Devellis B, Weinberger M, Devellis R, Tudor G and Beard A.
(2008). Communication about depression during rheumatoid arthritis patient visits. Arthritis
Care & Research. Vol 59, Issue 2, pp 186-191
* Nusbaum MRH, Frasier PY, Rojas F, Trotter K, and Tudor G. (2008). Sexual
Orientation and Sexual Health Care Needs: A Comparison of Women Beneficiaries in Outpatient
Military Health Care Settings. Journal of Homosexuality, 54(3): 259–276.
* Tudor, GE. (2006). Teaching Introductory Statistics Online – Satisfying the Students.
Journal of Statistics Education Volume 14, Number 3, www.amstat.org/publications/jse/v14n3/
* Potthoff, RF, Tudor, GE, Pieper, KS, and Hasselblad, V. (2006). Is it safe to assume
MAR for missing data in medical studies? Statistics in Medical Research. Vol. 15: 213-214
* Tudor GE and Koch GG (2000). Statistical methods for crossover designs in bioenvironmental
and public health studies. Handbook of Statistics, Vol. 18: Bio-Environmental and Public Health
Statistics, pp. 571-614.
Assistant Professor, Mathematics, School of Science and Humanities
Instructor, Anatomy & Physiology, School of Science and Humanities
Professor Emeritus, School of Science and Humanities
Faculty Athletic Representative, Athletics
Professor, English, School of Science and Humanities
Assistant Professor, Anatomy & Physiology